CPDA Conference 2024

Dr. Marc Caron

Dr. Marc Caron

Marc G. Caron is a native of Quebec, obtained a BSc in biochemistry from Laval University and his Ph.D. at the University of Miami. After a two-year postdoctoral fellowship at Duke University in 1973 to 1975, he became Assistant Professor in the Department of Physiology, Laval University. In 1977 he returned to a faculty position at Duke University Medical Center where he has been since. He is James B. Duke Professor of Cell Biology with secondary appointments in Medicine and Neurobiology. From 1981 until 2004, he was associated with the HHMI at Duke University, initially as a Senior Associate and then as an Investigator. His long-standing research interests have been in the mechanisms and regulation of G protein-coupled receptors and neurotransmitter transporters. He has authored more than 700 publications and served as Editor or editorial board member of several leading journals. He has trained and mentored more than 130 postdoctoral and clinical fellows as well as more than 12 graduate students. Dr. Caron has delivered numerous named and plenary lectures as well as obtained several distinctions, most recently including: The Lieber Prize for Schizophrenia Research, Brain and Behavior Research Foundation (NARSAD) (2013), election as a Fellow of AAAS (2013) and Member of the American Academy of Art and Sciences (2015).

Marc Caron, “Modulating Functional Selectivity of Endogenous GPCR Ligand by an Allosteric Actuator: The SBI-553 NRT1 ligand reverses intravenous cocaine/opiate abuse in mice”

17th Floor, East Village

The neurotensin (NT) system is an endogenous regulator of central dopaminergic neurotransmission and peptide neurotensin receptor 1 (NTR1) agonists have shown efficacy in animal models of schizophrenia and addiction. Several decades of effort to identify small molecule NTR1 agonists in Gq protein-based assays have led to very few drug candidates. Through the MLPCN effort and […]

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