CPDA Conference 2025

Dr. Vsevolod Katritch

Dr. Vsevolod Katritch

Dr Vsevolod “Seva” Katritch is a computational structural biologist at University of Southern California (USC) and a founding member of the Bridge Institute and Michelson Center for Convergent Biosciences at USC. His research focuses on developing and applying computational tools to study molecular function of membrane proteins, specifically the superfamily of G protein-coupled receptors (GPCRs). These tools are applied to structure-based discovery of ligands and in vivo probes for GPCRs, as well as in computer-assisted design of stabilized GPCR constructs for crystallization. His group works in close collaboration with crystallographers, biophysicists, molecular biologists, and medicinal chemists at the Bridge Institute, USC, the GPCR Consortium, and other institutions.

Dr. Katritch received his Ph.D from Moscow Institute of Physics and Technology, followed by postdoctoral training at Rutgers University and The Scripps Research Institute. Before joining USC, he served as a director of computational biology in a biotechnology startup and held research faculty positions at the University of California, San Diego and The Scripps Research Institute. His work has resulted in more than 90 publications, including ligand-discovery studies and high-impact reviews on GPCR structure and function. In 2017 he was named among Clarivate Analytics highly cited researchers in pharmacology and toxicology, as well as in the biology and biochemistry categories.

Vsevolod Katritch, “Structure based discovery of Angiotensin AT2 inhibitors for neuropathic pain relief”

17th Floor, East Village

The angiotensin II receptors AT1R and AT2R are the key components of the renin-angiotensin-aldosterone system. While AT1R is important for the blood pressure control, the less studied AT2R has a variety of reported neurological effects including regulation of growth and sensitivity of neurons. As such, AT2R inhibition has emerged as a potential target for chronic […]

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